Ligandrol (LGD-4033)

We love to write about LGD-4033.

It is one of our favorite SARMS in the world and going by its recent popularity among gym-rats, we aren’t alone either.

For the uninitiated though, LGD 4033 is one of those compounds that seems to be perpetually shrouded in mystery.

Effective vs. not effective! Sides vs. no sides. Need PCT vs. no PCT required.

There’s so much contradictory information about LGD4033 on the internet these days, that it’s no surprise that newbies end up confused.

The fact is that LGD 4033 is one of the strongest SARMS ever. It is the closest that you can get to anabolic steroids and it can completely transform your body within a span of weeks.

So, it’s a given that you have to use it responsibly to maximize the results while minimizing the side effects.

‘Wait. Did you just mention side effects?’

Oh yes, we did. Anyone who expects SARMS to be a free ride is misinformed.

Read on to know more.

History of LGD-4033

LGD-4033, also known as Anabolicum, Ligandrol or VK5211 is a SARM that was developed by Ligand Pharmaceuticals in the early 2000s.

The drug entered Phase I clinical trials in 2009 to analyze its effectiveness in the treatment of metabolic diseases and muscle wasting.

It was subsequently licensed to Viking Pharmaceuticals who are continuing to develop the drug for therapeutic applications.

LGD4033 is a selective androgen receptor modulator that shows remarkable efficacy in binding to bone and muscle tissue while sparing the prostate in men.

This translates into anabolic effects with zero risk of androgenic side effects in men and women.

Think using a mild dose of Testosterone, something like a TRT dose without the risk of gynecomastia or crazy blood pressure spikes or virilization.

It is widely believed that Ligandrol will one day replace androgenic hormones for performance enhancement. Will it be as effective as exogenous testosterone?  Probably not. But what’s more important is that it’s less likely to permanently damage your HPTA.

Clinical studies of Ligandrol

LGD-4033, along with Ostarine are the two SARMS that have made it to human clinical trials.

Study 1:

What it says: LGD4033 is safe, has an excellent pharmacokinetic profile and increases lean muscle mass without any adverse effect on the prostate gland.

Study 2:

What it says: LGD 4033 increases lean muscle mass as well as strength and speed. The side effects, if any, are very mild and completely reversible.

LGD-4033 was safe and well tolerated at all doses

No drug-related severe or serious AEs occurred

All adverse events were mild or moderate

No event led to study discontinuation

Safety and Tolerability of LGD-4033, a Novel Non-Steroidal OralSelective Androgen Receptor Modulator (SARM), in Healthy Men

Benefits of Ligandrol

The name pretty much sums it up.

Ligandrol is the Testosterone of the SARMS world. You can expect all the benefits of a test cycle without the side effects.

Muscle mass:

Ligandrol is the go-to compound for SARMS bulking cycles. It binds to androgen receptors in muscle tissue and amplifies the rate at which the body builds new muscle tissue. Being very similar to testosterone, it will also make your body hold on to some water and glycogen. Which means that the gains will not be very dry. Also, you will lose some of the gains when you come off the compound. If you are looking for lean and dry muscle gains, then we recommend that you check our stacks mentioned below.

Pumps:

Fuller, harder muscles all through your cycle and even afterwards. The muscle pumps with Ligandrol are legendary.

Strength:

There will be a noticeable increase in strength that allows you to break your past bests. Very useful if you are looking to keep up the gains between two steroid blasts. Not PCT mind you. Do not run SARMS during PCT as they are suppressive. But if you have healed completely and are not looking to pin again for a while, run Lignadrol with MK-677 for some great results.

Vascularity:

It’s not the best option for bulging and throbbing veins. But it does make you appear more vascular. Clubbed with the pumps and the muscle fullness, it’s pretty amazing.

Side Effects of LGD-4033

It has become extremely difficult to find a pure, unadulterated batch of SARMS these days thanks to Chinese suppliers who have invaded the market with their cheap knock-offs.

So, we have people talking about side effects like hair loss, high BP and even gyno which has nothing to do with SARMS.

LGD-4033 does not aromatize. It does not enlarge the prostate. Nor does it increase HCT which means that your blood does not turn into sludge. It does not cause hair loss or shedding. If you are experiencing any of these sides, you might want to evaluate the quality of the SARMS you bought.

We highly recommend Esarms. None of the suppliers even come close in terms of quality and pricing. Great customer support too.

All said and done, here are some of the side effects that you WILL experience with Ligandrol.

• Suppression: Even 1mg/ED of Anabolicum caused suppression in one of the clinical studies. And suppression is highly dose dependent. So if you are using 10mg/ED as opposed to 5mg/ED, you are 2x more likely to be suppressed by the end of your cycle. And with suppression comes lethargy, lack of libido and even insomnia in some people. There are multiple ways to deal with the suppression. Some people recommend a mini PCT with clomid. We’d say that only use drugs if they are really required. Do bloodwork after a couple of weeks of your cycle and if your LSH and Test levels are way below baseline, then you might want to consider a PCT. Else, just run OCT supplements like HCGenerate and N2 Organ guard during your cycle and you should be fine.

Ligandrol Stacks

Stacks are not really necessary to get results with SARMS. But there’s a bit of trial and error involved in everything related to PEDs.

We have personally stacked up to 4 SARMS at a time and gotten terrific results with it.

Results that would put a minor steroid cycle to shame.

But it’s totally up to you. A stack increases the risk of a shutdown manifold. You are also more likely to experience some other side effects.

But a shutdown never stopped anyone from using PEDs, did it?

Here you go.

LGD-4033 Bulking stack:

LGD-4033 at 5mg/ED with RAD140 at 20mg/ED. Get ready for the ride of your life. The bulk will be insane if you eat right and lift well.

LGD-4033 Cutting Stack:

Ligandrol is not the best cutting SARM due to the water and glycogen that you gain. However, you can still stack it with S-4 for a calorie deficit bulk. You should be able to lose fat and gain muscle at the same time.