Cardarine or GW501516 has been having a rough ride off late.
It was quite popular with athletes once upon a time.
But then WADA poked its know-it-all nose and issued multiple statements about the carcinogenic nature of the compound, that seems to have populated the internet these days.
And yet, professional athletes are caught doping with it. Surprise, surprise!
The most recent addition to the list is Jarell ‘Big Baby’ Miller, the #1 heavyweight title contender who tested positive for GW in March this year.
All this talk about cancer is pathetic to be honest.
The study that caused the cancer growth was pretty dubious. We will talk about it in a while.
GW501516 or Endurobol is one of the most effective compounds that we have used in the past few years.
It makes cardio on Trenbolone a cakewalk. That should help any steroid user understand the effectiveness of the compound.
And even if you aren’t a roid user, it massively reduces the effort needed to pump out more reps, do more sets, complete more rounds on the track or hit your best in HIIT.
In a nutshell, it is the perfect PED for newbies, seasoned users, athletes or even the rookie gym goer.
History of Cardarine
Endurobol or Cardarine, also known by chemical names like GW501516 & GSK-516 (we will be using the names interchangeably in this blog post) is a peroxisome proliferator-activated receptor (PPAR) beta agonist that was formulated in the 1990s in a collaboration between Ligand and GSK.
It was for long considered a star candidate for the treatment of metabolic diseases.
Also, it was being considered as a potential treatment for Diabetes, Cardiovascular diseases, improving bone density and reducing obesity.
That’s before phase III of animal testing revealed that it could help cancer cells grow like ‘weed on fertilizer’.
The studies were abandoned. GW501506 was dusted under the carpet and GSK and Ligand moved on to better prospects.
But enough data about the positives of the compound had already made its way into the public domain. Bodybuilders and athletes were already experimenting with GW in the early 2000s. And the results were too good to ignore.
When it was taken off the shelves, the black market for the drug just exploded and it joined the ranks of anabolic steroids and SARMS that sadly, are available only in UG labs.
Everybody, even people who do not have the faintest idea of how GW works, are bashing it these days on messaging boards.
‘That shit causes cancer bro. I wouldn’t touch it with a barge pole’
We bet that you’ve read that before.
Cardarine and Cancer
The fact is that the studies are not conclusive and in fact, are contradictory.
The first study that detected that GW501516 could promote the proliferation of cancerous cells in mice was conducted at absurdly high doses in knockout rats.
Somewhere along the lines of 5mg/kg of bodyweight per day for 104-weeks.
We cannot find the link to that study anymore. Seems to have been taken down.
There are two very important things to consider.
- If you administer drugs that are considered ‘safe’ for human consumption by the FDA, at doses that are 20x more than the recommended levels for insanely long durations, it would cause some serious side effects. Let’s say you take Tylenol at 20x the recommended dose every day for a month. You would probably poop your liver out on the 7th day itself.
- This study was conducted by mixing Cardarine with DMBA, which is a known carcinogen.
Cardarine and HDL
On the other hand, there are at least five clinical studies that prove that GW501506 has a plethora of beneficial effects including, increasing serum high-density lipoprotein (HDL), increasing skeletal muscle fatty acid catabolism, amplifying the rate of recovery in a damaged liver and possibly even reducing the proliferation of cancer cells.
The only promising PPARδ agonist thus far is GW501516…In preclinical trials, treatment with this agonist increased lipid metabolism and increased HDL levels, while preventing weight gain on a high-fat diet in mice, and protected animals against developing type II diabetes.Rationally designed PPARδ-specific agonists and their therapeutic potential for metabolic syndrome [PMC]
So, yes, G501516 was linked to cancer in mice in one study. But that study was dubious according to us. More data is needed on how humans react to long term use of this compound.
In short doses and short durations, GW501516 seems to be relatively safe.
Benefits of GW501516
Let’s talk about the benefits of Cardarine.
Changes the energy source:
Without sounding too geeky, Cardarine causes a shift inside muscle cells which changes the source of energy that these cells utilize. Cells that otherwise use glucose for energy will shift to using stored fat instead. That changes your body in more ways than one. You will be able to pump out more reps or go for longer on runs without getting tired or without increasing your food intake. At the same time, it helps burn stored fat.
This is an effect of Endurobol that we’ve rarely seen discussed. Animal research reveals that with continual use, Cardarine may alter the composition of your existing muscle fiber and even promote hyperplasia, or the formation of new muscle fibers. Think about anabolism in a cutting cycle, which is where it shines.
Cardarine is very effective in helping increase the levels of HDL while reducing the levels of LDL and total cholesterol. For long term anabolic steroid users or even new users who are using oral steroids, that’s a very effective way to control hyperlipidemia during cycles.
Insulin Sensitivity :
Endurobol improves the rate at which your body utilizes glucose. This reduces the risk of developing metabolic diseases like Type II Diabetes. It will also help prevent weight gain.
Heals your liver:
Again, if you are a long term steroid user or primarily use oral steroids that are harsh on your liver, how about adding GW to your stack along with TUDCA? It can amplify the rate at which your liver recovers.
Side Effects of Cardarine
Apart from the exaggerated cancer risk, Cardarine causes no acute side effects at recommended doses.
Not even the occasional headache or insomnia that many SARMS cause.
It is one of the best and most easily tolerated compounds that we’ve ever used.
Start with a low dose, say 5mg/day for two to three weeks and then up it to 10mg/day.
You should get great results with that dose. Only if you don’t, you might consider increasing it further to say 20mg/day.
Do not exceed 20mg as the rewards start to taper as the dose increases.